Carbidopa and Levodopa

10mg/100mg

Product Details

Product Name:
Carbidopa and Levodopa
Strength:
10mg/100mg
Count:
100
NDC:
42291-471-01
Class:
Rx
Brand Name(s):
Sinemet
Imprint Code:
TV;9701
Color(s):
blue (dark blue, mottled)
Shape:
Round
Score:
No score
Case Count:
Inactive Ingredients:
corn starch, magnesium stearate, microcrystalline cellulose, pregelatinized starch (maize). In addition, the 25 mg/100 mg strength contain D&C yellow #10 aluminum lake and FD&C yellow #6 aluminum lake (sunset yellow lake). The 10 mg/100 mg and 25 mg/250 mg strengths contain FD&C blue #2 aluminum lake.
Indications and Usage:

Carbidopa and levodopa tablets are indicated in the treatment of Parkinson’s disease, post-encephalitic parkinsonism, and symptomatic parkinsonism that may follow carbon monoxide intoxication or manganese intoxication.

Carbidopa allows patients treated for Parkinson’s disease to use much lower doses of levodopa. Some patients who responded poorly to levodopa have improved on carbidopa and levodopa. This is most likely due to decreased peripheral decarboxylation of levodopa caused by administration of carbidopa rather than by a primary effect of carbidopa on the nervous system. Carbidopa has not been shown to enhance the intrinsic efficacy of levodopa.

Carbidopa may also reduce nausea and vomiting and permit more rapid titration of levodopa.

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